Explore the top five must-visit places on a road trip from Baltimore, Maryland to Louisville, Kentucky. Discover historic battlefields, natural wonders, and world-class attractions on this unforgettable adventure.

Planning a Baltimore to Louisville road trip? Check the fuel and toll costs of different routes from the I-70 to I-64 to the I-81 to I-64 and I-95 to I-64.

Plan your road trip from Baltimore to Louisville with our guide highlighting the fastest and slowest routes, distances and estimated driving times during traffic patterns.